Cytokine regulation by virus infection: Bovine viral diarrhea virus, a flavivirus, downregulates production of tumor necrosis factor alpha in macrophages in vitro
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Journal of Virology;70(4): 2650-2653
Permanent link to this item: http://hdl.handle.net/10568/33023
Internet URL: http://jvi.asm.org/content/70/4/2650.full.pdf
Bovine bone marrow-derived macrophages were infected in vitro with non-cytopathic or cytopathic strains of bovine viral diarrhoea virus. Infection with both biotypes resulted in a decreased production of tumour necrosis factor alpha upon stimulation with heat-inactivated Salmonella dublin or lipopolysaccharide. Other macrophage functions were not downregulated, indicating that the observed effect was not due to a loss in macrophage viability. The downregulated production of tumour necrosis factor alpha in infected macrophages may contribute to the well-documented immunosuppression in animals infected with bovine viral diarrhoea virus.