CGSpaceA Repository of Agricultural Research Outputs
    View Item 
    •   CGSpace Home
    • International Livestock Research Institute (ILRI)
    • ILRI archive
    • View Item
       
    • CGSpace Home
    • International Livestock Research Institute (ILRI)
    • ILRI archive
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Vaccines against Theileria parva

    Thumbnail
    
    Authors
    Morzaria, S.P.
    Nene, Vishvanath
    Bishop, Richard
    Musoke, A.J.
    Date
    2000
    Language
    en
    Type
    Journal Article
    Accessibility
    Limited Access
    Metadata
    Show full item record
    Share
    Citation
    New York Academy of Sciences. Annals;916: 465-473
    Permanent link to cite or share this item: http://hdl.handle.net/10568/33081
    DOI: https://dx.doi.org/10.1111/j.1749-6632.2000.tb05326.x
    Abstract/Description
    Bovine theileriosis caused by Theileria parva continues to be a major economic problem in many parts of Eastern, Southern, and Central Africa. Due to the unsustainable nature or the present control method-using toxic acaricides to kill ticks - alternative control methods are being sought. Live vaccines are being used in many countries in the region. 'These vaccines are based on the infective sporozoite stage of the parasite. Sporozoites are inoculated in cattle with simultaneous administration of a long-acting formulation of oxytetracycline. These vaccines are poorly adopted in the region, mainly because of problems associated with the use of live parasites. An experimental recombinant vaccine based on a sporozoite surface antigen (p67) has been developed. Immunization with this antigen induces neutralizing antibodies and, under laboratory conditions, this technique protects approximately 70% of the immunized cattle to a defined needle challenge. The efficacy of the vaccine is currently being evaluated under field challenge in Kenya. Since a vaccine based on a single antigen may not be sustainable under field conditions, a search for schizont antigens that induce protective cell-mediated immune responses continues. It is expected that the ultimate vaccine against theileriosis will incorporate a mixture of several antigens derived from both sporozoite and schizont stages, contributing to robust immunity.
    AGROVOC Keywords
    THEILERIA PARVA; VACCINES; IMMUNITY; DRUG RESISTANCE; CATTLE; BREEDS; IMMUNIZATION; ANTIGENES
    Subjects
    CATTLE; VACCINES; BREEDS; GENETICS; LIVESTOCK;
    Collections
    • ILRI articles in journals [4825]
    • ILRI archive [4979]

    AboutSend Feedback
     

    My Account

    LoginRegister

    Browse

    All of CGSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesBy AGROVOC keywordBy ILRI subjectBy CPWF subjectBy CCAFS subjectBy CIFOR subjectBy IWMI subjectBy RegionBy CountryBy SubregionBy CRP subjectBy River basinBy Output typeBy CTA subjectBy WLE subjectBy Bioversity subjectBy CIAT subjectBy CIP subjectBy animal breedBy CGIAR System subjectThis CollectionBy Issue DateAuthorsTitlesBy AGROVOC keywordBy ILRI subjectBy CPWF subjectBy CCAFS subjectBy CIFOR subjectBy IWMI subjectBy RegionBy CountryBy SubregionBy CRP subjectBy River basinBy Output typeBy CTA subjectBy WLE subjectBy Bioversity subjectBy CIAT subjectBy CIP subjectBy animal breedBy CGIAR System subject

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    AboutSend Feedback