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dc.contributor.authorMenge, D.M.
dc.contributor.authorBehnke, J.M.
dc.contributor.authorLowe, A.
dc.contributor.authorGibson, John P.
dc.contributor.authorIraqi, F.A.
dc.contributor.authorBaker, R.L.
dc.contributor.authorWakelin, D.
dc.date.accessioned2013-07-03T05:26:02Z
dc.date.available2013-07-03T05:26:02Z
dc.date.issued2003
dc.identifier.citationParasite Immunology;25(6): 341-349
dc.identifier.issn0141 9838
dc.identifier.urihttp://hdl.handle.net/10568/33089
dc.description.abstractThis paper reports the results of a genome-wide search for quantitative trait loci (QTL) influencing immunological responses to infection with the gastro-intestinal nematode parasite Heligmosomoides polygyrus in an F2 population created by crossing the resistant SWR and the susceptible CBA inbred mouse strains. Following infections, intestinal granuloma score at post mortem, mucosal mast cell protease 1, and IgE and IgG1 titres were recorded. The susceptible CBA mice had significantly higher IgG1, but significantly lower IgE, mucosal mast cell protease 1 and granuloma scores than SWR mice. Significant QTL were mapped to chromosomes 4, 11, 13 and 17 for granuloma score; chromosomes 12 and 17 for IgE; chromosome 10, 17 and 18 for IgG1 and chromosomes 1, 9, 10, 11, 17 and 18 for mucosal mast cell protease 1. Chromosomes 10, 11, 17 and 18 had QTL affecting more than one trait, and these are most likely to represent single QTL with multiple effects rather than multiple QTL. Some of these QTL map to regions known to harbour genes responsible for the induction of immunological responses to intestinal worms.
dc.language.isoen
dc.sourceParasite Immunology
dc.subjectNEMATODA
dc.subjectMICE
dc.subjectCHROMOSOMES
dc.subjectGENETIC MAPS
dc.subjectIMMUNOLOGICAL FACTORS
dc.subjectDIGESTIVE SYSTEM DISEASES
dc.subjectINFECTION
dc.subjectGENOTYPES
dc.subjectIMMUNOGLOBULINS [GLYCOPROTEINS]
dc.titleMapping of chromosomal regions influencing immunological responses to gastrointestinal nematode infections in mice
dc.typeJournal Article
cg.subject.ilriGENETICS
cg.subject.ilriANIMAL DISEASES
cg.subject.ilriLIVESTOCK
cg.subject.ilriGENETICS
cg.identifier.statusLimited Access
cg.identifier.doihttps://dx.doi.org/10.1046/j.1365-3024.2003.00640.x


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