Genetic basis of trypanotolerance in cattle and mice
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Parasitology Today;14(11): 450-454
Permanent link to this item: http://hdl.handle.net/10568/33102
Under most circumstances, certain breeds of domestic ruminants show a remarkable resistance to the effects of African trypanosomiasis: they can tolerate the presence of parasites while apparently controlling levels of parasitaemia and, crucially, not showing the the severe anaemia and production loss that are characteristic of infection in susceptible hosts. As discussed in this review, the genetic control of this phenomenon might finally be yielding to gene mapping studies. Genetic regions determining susceptibility to trypanosomiasis in mice have been identified and parallel studies are well advanced in cattle. There is growing evidence that only modest numbers of genes are involved in determining the difference between a susceptible and a resistant animal. These observations raise a new series of important questions concerning the possible exploitation of major trypanotolerance genes and the way that they might function in different genetic and physical environments. Topics covered include trypanotolerant livestock; the mouse model; immunology; the genetic basis of trypanotolerance; the gene mapping approach (bovine trypanotolerance mapping, murine trypanotolerance mapping) and applications.
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