Genetic control of resistance to trypanosomiasis
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Kemp, S.J., Darvasi, A., Soller, M. and Teale, A.J. 1996. Genetic control of resistance to trypanosomiasis. Veterinary Immunology and Immunopathology 54(1-4): 239-243.
Permanent link to this item: http://hdl.handle.net/10568/35333
To map the genetic sources of trypanotolerance in mice, a linkage analysis of survival following trypanosome challenge was performed by selective genotyping in a large F2 population produced by crossing the resistant C57BL/6 and susceptible BALB/c inbred mouse lines. We report evidence of a chromosomal region of large effect, possibly comprising more than one resistance locus, on Chromosome 17; and of further loci on Chromosomes 1 and 5. Together, these genes can account for all of the difference between the mean parental phenotypes.