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dc.contributor.authorKonde, V.
dc.contributor.authorMajiwa, P.A.O.
dc.date.accessioned2014-10-31T06:08:50Z
dc.date.available2014-10-31T06:08:50Z
dc.date.issued2000
dc.identifier.urihttp://hdl.handle.net/10568/50133
dc.description.abstractIn order to search for T. congolense genes whose transcription status may be influenced by response to isometamidium chloride, we applied the Representational Difference Analysis (RDA) (Lisitsyn et al., 1993; Hubank & Schatz, 1994) to the comparative analysis of cDNA synthesised from two isogenic trypanosome clones, the isometamidium chloride sensitive T. congolense ILI 180 (Nantulya et al., 1984) and its resistant derivative, IL3343 (Peregrine et al., 1997). Three major categories of genes were found: (i) those transcribed only in the trypanosome clone sensitive to isometamidium chloride, (ii) those transcribed more abundantly in only one of the two isogenic trypanosome clones, and (iii) those that are transcribed at approximately the same level, but which detect highly polymorphic loci in the isogenic trypanosome clones.
dc.language.isoen
dc.publisherEuropean Union Concerted Action on Integrated Control of Pathogenic Trypanosomes and their Vectors
dc.relation.ispartofseriesICPTV Newsletter; 2
dc.subjectTRYPANOSOMA CONGOLENSE
dc.subjectGENES
dc.subjectDRUG RESISTANCE
dc.titleAlterations in gene transcription patterns associated with the Development of isometamidium resistance in Trypanosoma congolense
dc.typeConference Paper
cg.subject.ilriTRYPANOSOMIASIS
cg.subject.ilriANIMAL DISEASES
cg.subject.ilriLIVESTOCK
cg.identifier.statusLimited Access


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