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dc.contributor.authorCallaby, R.
dc.contributor.authorHanotte, Olivier H.
dc.contributor.authorWyk, I.C. van
dc.contributor.authorKiara, Henry K.
dc.contributor.authorToye, Philip G.
dc.contributor.authorMbole-Kariuki, Mary N.
dc.contributor.authorJennings, A.
dc.contributor.authorThumbi, S.M.
dc.contributor.authorCoetzer, J.A.W.
dc.contributor.authorBronsvoort, B.M. de C.
dc.contributor.authorKnott, S.A.
dc.contributor.authorWoolhouse, M.E.J.
dc.contributor.authorKruuk, L.E.B.
dc.date.accessioned2015-07-27T07:48:03Z
dc.date.available2015-07-27T07:48:03Z
dc.date.issued2015-03-15
dc.identifier.citationCallaby, R., Hanotte, O., Wyk, I.C. van, Kiara, H., Toye, P.G., Mbole-Kariuk, M.N., Jennings, A., Thumbi, S.M., Coetzer, J.A.W., Bronsvoort, B.M. De. C., Knott, S.A., Woolhouse, M.E.J. and Kruuk, L.E.B. 2015. Variation and covariation in strongyle infection in East African shorthorn zebu calves. Parasitology 142(3):499-511.en_US
dc.identifier.issn1469-8161
dc.identifier.urihttps://hdl.handle.net/10568/67376
dc.description.abstractParasite burden varies widely between individuals within a population, and can covary with multiple aspects of individual phenotype. Here we investigate the sources of variation in faecal strongyle eggs counts, and its association with body weight and a suite of haematological measures, in a cohort of indigenous zebu calves in Western Kenya, using relatedness matrices reconstructed from single nucleotide polymorphism (SNP) genotypes. Strongyle egg count was heritable (h2 = 23·9%, s.e. = 11·8%) and we also found heritability of white blood cell counts (WBC) (h2 = 27·6%, s.e. = 10·6%). All the traits investigated showed negative phenotypic covariances with strongyle egg count throughout the first year: high worm counts were associated with low values of WBC, red blood cell count, total serum protein and absolute eosinophil count. Furthermore, calf body weight at 1 week old was a significant predictor of strongyle EPG at 16–51 weeks, with smaller calves having a higher strongyle egg count later in life. Our results indicate a genetic basis to strongyle EPG in this population, and also reveal consistently strong negative associations between strongyle infection and other important aspects of the multivariate phenotype.en_US
dc.language.isoenen_US
dc.sourceParasitologyen_US
dc.subjectANIMAL DISEASESen_US
dc.subjectANIMAL BREEDINGen_US
dc.titleVariation and covariation in strongyle infection in East African shorthorn zebu calvesen_US
dc.description.versionPeer Reviewen_US
dc.typeJournal Articleen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.subject.ilriANIMAL BREEDINGen_US
cg.subject.ilriANIMAL DISEASESen_US
cg.subject.ilriCATTLEen_US
cg.subject.ilriLIVESTOCKen_US
cg.identifier.statusOpen Accessen_US
cg.contributor.affiliationUniversity of Edinburgh
cg.contributor.affiliationUniversity of Nottingham
cg.contributor.affiliationUniversity of Pretoria
cg.contributor.affiliationInternational Livestock Research Institute
cg.contributor.affiliationAfrican Union Interafrican Bureau for Animal Resources
cg.contributor.affiliationJames Hutton Institute
cg.contributor.affiliationAustralian National University
cg.targetaudienceSCIENTISTSen_US
cg.fulltextstatusFormally Publisheden_US
cg.identifier.doihttps://dx.doi.org/10.1017/S0031182014001498en_US
cg.isijournalISI Journalen_US
cg.coverage.regionAFRICAen_US
cg.coverage.regionEAST AFRICAen_US
cg.contributor.crpLivestock and Fish


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