Mapping Food Quality to Improve Human and Planetary Health The Periodic Table of Food Initiative (PTFI) is accelerating this future by providing foundational resources to map food quality on the basis of robust food composition data and associated environmental, agricultural, and cultural variables. Our ultimate translational goal is to empower stakeholders to develop data-driven solutions to society’s most pressing food system challenges: biodiversity loss, climate change, and malnutrition. CHALLENGES & OPPORTUNITIES Food System Challenges. Diet-related diseases account for 1 in 5 deaths around the world, while dominant farming practices compromise the health of ecosystems and our planet. These challenges disproportionately impact the world’s most vulnerable populations and are exacerbated by climate change. We need to transform food systems for healthier people and a healthier planet in a changing world. By better knowing our food, we can each make better decisions for people and the planet. What is in Food? Food is diverse and dynamic. The planet has over 30,000 edible species. These species are composed of thousands of components, also known as biomolecules, including macronutrients, micronutrients, and specialized metabolites. Additional components enter food through agricultural production and processing. These components serve diverse functions in ecosystems and in our bodies. The quantity of these components varies during food’s journey from farm to table. Imagine a world where farmers cultivate foods to combat diet-related chronic diseases in their local communities using practices that are nourishing for the environment. A world where people everywhere have access to sustainable and safe diets that support their cultural preferences and vitality. This future harnesses the power of food not only as a solution to hunger, but as an essential resource to support the wellbeing of people and the planet. The science of characterizing food components has evolved from consideration of food as an energy source to understanding the role of essential nutrients for public health. In addition to the known macro- and micronutrients, lesser-known specialized metabolites are increasingly recognized for their potential role in supporting health. Some food components may also be deleterious to health in specific dosages. While science has made major strides in cataloging food composition, we still don’t have a complete picture of what is in the food we grow and eat. Discovery data indicates there are thousands of unknown components in food, still yet to be named and explored. For the first time in history, with advanced analytics and global coordination, we can imagine knowing the complete composition of food, and how it varies across the food system. The Periodic Table of Food Initiative is catalyzing this future through the innovation of standardized multi-omics tools and global capacity strengthening efforts to characterize food components of the world’s food supply. This knowledge will complement existing standardized measurements of essential nutrients, allowing us to better understand the role of food in both human and planetary health. Application of PTFI data for solutions across the food system 1 “A database that captures and quantifies the molecular content of food will revolutionize the agriculture, food and health sectors. Once in place, this publicly accessible database will be the greatest single knowledge asset in the history of food.” Bruce German, Ph.D. Distinguished Professor and Chemist, University of California, Davis Source: Ahmed et al. 2022. Frontiers in Nutrition DOI:10.3389/fnut.2022.874312 Mapping Food Quality to Improve Human and Planetary Health MISSION The Periodic Table of Food Initiative is providing standardized tools, data, and training to map food quality of the world's edible biodiversity. We are mapping food quality based on diverse components and their variation across the food system. VISION We envision a world where each stakeholder involved in food and health systems is empowered to develop data-driven solutions for enhanced human and planetary health. OFFERINGS + CURRENT STATE We are building a global ecosystem of partners to map food components to better know our food and diets through the following offerings. Tools. We are developing and distributing standardized analytical methods based on omics technology to catalog the diversity of components in food to complement traditional food composition methods. Our current toolbox includes standardized methods to quantify minerals and metals (Ionomics), fats (Lipidomics), and specialized metabolites and other small molecules (Metabolomics), as well as a platform to facilitate the discovery of novel food biomolecules. We are currently developing a Glycomics method to measure the wide variety of fibers in food. Data. We have developed standardized methods and centralized data pipelines to harmonize food composition data generated from labs around the world. This technology harnesses computational science innovation to confidently annotate components in food using automated data processing. We are simultaneously collecting meta-data to link food composition data with diverse drivers of environmental, geographic, agricultural, and cultural variation. To date, we have populated the Periodic Table of Food database with an initial 200 foods analyzed across our suite of analytical platforms. Our team is taking a transparent approach to Access and Benefit Sharing related to food procurement and data use based on international regulatory frameworks and ethical considerations. We will make food composition data and supporting meta-data available in an open-access data platform as a global public resource. Training. Through our capacity strengthening arm, Food EDU, we are providing innovative education based on a unique model that integrates cutting-edge research, training, and data applications to educate and inspire the next generation of food, agriculture, health, and nutrition leaders. We are currently developing our first Food EDU course module: Foodomics + Society. Further, we are providing training to a cohort of Good Food Fellows who will implement PTFI tools to carry out community-engaged research projects. Global Ecosystem. We have built an ecosystem of partners, including Centers of Excellence on each continent, to utilize PTFI tools and data to address locally-relevant research quetions. We have further identified initial National Lab Hubs and Partner Labs that are adopting PTFI tools to profile their local edible biodiversity. Additionally, our ecosystem entails research partners that contribute to methodological innovation and lead demonstration projects. Research and Translation. We are supporting a range of transdisciplinary demonstration projects that apply PTFI tools and data in the following priority areas: (1) regenerative agriculture and agroecology; (2) climate change solutions and; (3) diet-related chronic disease. 2 PTFI DEMONSTRATION PROJECTS Investigating Underutilized Traditional Crop Mixtures For Nutritional Yield, Climate Resilience, and Soil Regeneration PI: Dr. Alex C McAlvay | The New York Botanical Garden, Ethiopian Public Health Institute, Addis Ababa University, Ethiopian Biodiversity Institute Whole Grains International: Integrating PTFI With Soil to Society Research in Rwanda and Washington State, USA PI: Dr. Kevin Murphy, Co-Investigator: Dr. Cedric Habiyaremye | Washington State University Precision Protein-Based Food Products for an Equitable, Sustainable, and Healthy Global Population PI: Justin B. Siegel, Co-Investigators: Carlito Lebrilla, Keith Baar, Ilias Tagkopoulos | UC Davis IIFH Unlocking the Nutritional Potential of Potato PI: Jessica Chitwood-Brown and Sahar Toulabi | Colorado State University Biomarkers of Fruit and Vegetable Intake PI: Tiffany Weir | Colorado State University World Food Map PI: Dr. Anna Herforth, Co-Investigator: Prof. Edith Feskens | Wageningen University Preservation of Fermented Food Microbiota for Human Health PI: Prof. Nicholas Bokulich, Co-Investigators: Prof. Pascale Vonaesch, University of Lausanne; Prof. Adrian Egli, University of Basel; Prof. Maria Gloria Dominguez-Bello, Rutgers University | ETH Zürich 1000 Farms Initiative: Data Scaling for Regenerative Agriculture and Supporting BIPOC Inclusion PI: Dr. Jonathan Lundgren | Ecdysis Foundation Soil Health, Food Composition, and Human Health PI: Dr. Reginald Annan, Co-Investigator: Dr. Endale Amare | Kwame Nkrumah University of Science and Technology and Ethiopia Public Health Institute REGENERATIVE AGRICULTURE + AGROECOLOGY DIET-RELATED CHRONIC DISEASE Mapping Food Quality to Improve Human and Planetary Health The PTFI is facilitating the collection of food composition data using standardized tools as a key resource to inform solutions for planetary health through three pathways: (1) Climate Effects on Food Quality. Food composition data collected over time and space can serve as an indicator and predictor of the impact of climate change on food quality. (2) Regenerative Agriculture and Agroecology. Food composition data can provide quantitative evidence for scaling farming practices that support people and the planet. (3) Planetary Health Diets. Food composition data can inform the design of diets for mitigating diet-related chronic disease, as well as climate change, that are place-based and accessible. Applications of Food Composition Data for Planetary Health GLOBAL LAUNCH OF PTFI DATA PLATFORM Join us April 23rd and 24th 2024 in New York City to celebrate the launch of PTFI’s foundational landmark resource to map the diverse components of food with reference data and fascinating data stories. Check foodperiodictable.org for details! FUTURE OUTLOOK Tools. We seek to continue to develop standardized tools to better know our food. In addition, we seek to develop decision-making tools for diverse food system stakeholders fueled by PTFI data to design solutions to urgent societal challenges. Data. With our global partners, we seek to populate the PTFI database with food composition data of the planet’s edible biodiversity. We further plan for PTFI tools to be used to generate data from research studies to elucidate how environmental, agricultural, and cultural factors impact food composition and implications for human and planetary health. Training. Through Food EDU, we aim to train and empower learners globally to apply PTFI data to design food system solutions. PTFI CENTERS OF EXCELLENCE, NATIONAL LAB HUBS & CORE LABS LEGEND CENTER OF EXCELLENCE NATIONAL LAB HUB CORE LAB 3 PTFI GLOBAL ECOSYSTEM Our vision is dependent on a global network of partners across sectors managed by the PTFI Secretariat, comprised of the American Heart Association and Alliance Bioversity CIAT. Mapping Food Quality to Improve Human and Planetary Health Maria Andrade International Potato Center, Peru Anna Lartey University of Ghana Barbara Burlingame Massey University, Riddet Institute, New Zealand Dariush Mozaffarian Tufts University Manuel Rameriz-Zea Institute of Nutrition for Central America and Panama; Research Center for Prevention of Chronic Diseases, Guatemala Howard-Yana Shapiro Center for International Forestry Research – World Agroforestry (CIFOR-ICRAF) Jennifer van Eyk Cedars-Sinai Precision Biomarker Laboratories Eran Segal Weizmann Institute of Science, Israel SCIENCE ADVISORY COMMITTEE TOOLS ADVISORS CAPACITY STRENGTHENING DATA, RESEARCH & TRANSLATION Bruce German, Chair University of California, Davis LEADERSHIP TECHNOLOGY PARTNERS ANALYTICON DISCOVERY BGI AMERICAS COLORADO STATE UNIVERSITY Jessica Prenni Lead, PTFI Core Lab PTFI CORE LAB METASCI SLING SINGAPORE LIPIDOMICS INCUBATOR UCLA LIPIDOMICS UNIVERSITY OF COLORADO ANSCHUTZ MEDICAL CAMPUS WEST COAST METABOLOMICS CENTER UT SOUTWESTERN MEDICAL CENTER VANDERBILT UNIVERSITY Steve Watkins Lead Strategist and Technical Advisor VERSO BIOSCIENCES Tracy Shafizadeh Director of Technology Partnerships Chi-Ming Chien Lead, Database Workstream CENTERS OF EXCELLENCE Ethiopian Public Health Institute Kwame Nkrumah University of Science & Technology, Ghana Mahidol University, Thailand National Institute of Nutrition and Health, Mexico Pontificia Universidad Javeriana, Colombia The University of Adelaide, Australia University of California, Davis, USA University of the South Pacific, Fiji Wageningen University & Research, Netherlands NATIONAL LAB PARTNERS Chinese Academy of Agricultural Sciences Ethiopian Public Health Institute National Agriculture and Food Organization, Japan National Institute of Nutrition, India United States Department of Agriculture TRANSLATION & RESEARCH PARTNERS Food + Planet Ecdysis Foundation ETH Zürich The New York Botanical Garden Washington State University World Food Map 4 Visit the PTFI website: www.foodperiodictable.com CONTACT Dr. Selena Ahmed, Global Director of the PTFI, American Heart Association selena.ahmed@heart.org FUNDING PARTNERS SEERAVE FOUNDATION FOURFOLD THE ROCKEFELLER FOUNDATION FOUNDATION FOR FOOD & AGRICULTURE RESEARCH ATRIA HEALTH COLLABORATIVE BILL & MELINDA GATES FOUNDATION LEADERSHIP FUNDING PARTNERS Roy Steiner Senior Vice President for the Food Initiative The Rockefeller Foundation John de la Parra Director, Global Food Portfolio The Rockefeller Foundation FOOD EDU GOO D FO O D FELLO W S Kevin Cody Senior Program Manager Food EDU / Good Food Fellows Jackie Bertoldo Senior Curriculum & Product Manager Food EDU / Good Food Fellows Chef Alejandra Schrader Chef Robert Oliver PTFI AMBASSADORS SECRETARIAT Tammy Gregory Executive VP of Healthcare Business Solutions, AHA Selena Ahmed PTFI Global Director, Food EDU Dean, AHA Greg Mandell Executive Advisor of Mission Advancement, AHA PTFI LEADERSHIP Maya Rajasekharan Director of Strategy Integration & Engagement, Alliance Gina Kennedy Director of Research, Translation & Impact, Alliance