Cross-sectional serosurvey of Leptospira species among slaughter pigs, goats, and sheep in Uganda

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cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationUniversity of Bernen
cg.contributor.affiliationMakerere Universityen
cg.contributor.affiliationNational Livestock Resources Research Institute, Ugandaen
cg.contributor.affiliationFederal Institute for Risk Assessment, Germanyen
cg.contributor.affiliationMinistry of Agriculture, Animal Industry and Fisheries, Ugandaen
cg.contributor.crpAgriculture for Nutrition and Health
cg.contributor.crpLivestock
cg.contributor.donorFederal Ministry for Economic Cooperation and Development, Germanyen
cg.contributor.donorCGIAR Trust Funden
cg.contributor.initiativeOne Health
cg.coverage.countryUganda
cg.coverage.iso3166-alpha2UG
cg.coverage.regionAfrica
cg.coverage.regionEastern Africa
cg.creator.identifierLordrick Alinaitwe: 0000-0002-5432-6407
cg.creator.identifierVelma Kivali: 0000-0003-0797-4484
cg.creator.identifierJames Bugeza: 0000-0002-8124-2807
cg.creator.identifierKristina Roesel: 0000-0002-2553-1129
cg.creator.identifierElizabeth Cook: 0000-0001-6081-8363
cg.creator.identifierMartin Wainaina: 0000-0002-4938-2543
cg.howPublishedFormally Publisheden
cg.identifier.dataurlhttps://hdl.handle.net/20.500.11766.1/FK2/BGBMSPen
cg.identifier.doihttps://doi.org/10.1371/journal.pntd.0012055en
cg.isijournalISI Journalen
cg.issn1935-2735en
cg.issue3en
cg.journalPLOS Neglected Tropical Diseasesen
cg.reviewStatusPeer Reviewen
cg.speciesLeptospira spp.en
cg.subject.actionAreaResilient Agrifood Systems
cg.subject.ilriANIMAL DISEASESen
cg.subject.ilriGOATSen
cg.subject.ilriPIGSen
cg.subject.ilriSHEEPen
cg.subject.ilriSMALL RUMINANTSen
cg.subject.ilriZOONOTIC DISEASESen
cg.subject.impactAreaNutrition, health and food security
cg.subject.impactPlatformNutrition, Health and Food Security
cg.subject.sdgSDG 3 - Good health and well-beingen
cg.volume18en
dc.contributor.authorAlinaitwe, Lordricken
dc.contributor.authorAturinda, C.J.en
dc.contributor.authorLubega, A.en
dc.contributor.authorKivali, Velmaen
dc.contributor.authorBugeza, Jamesen
dc.contributor.authorWainaina, M.en
dc.contributor.authorRichter, M.H.en
dc.contributor.authorHoona, J.J.en
dc.contributor.authorRoesel, Kristinaen
dc.contributor.authorMayer-Scholl, A.en
dc.contributor.authorCook, Elizabeth A.J.en
dc.contributor.authorKankya, C.en
dc.contributor.authorDürr, S.en
dc.date.accessioned2024-03-21T08:55:16Zen
dc.date.available2024-03-21T08:55:16Zen
dc.identifier.urihttps://hdl.handle.net/10568/140535
dc.titleCross-sectional serosurvey of Leptospira species among slaughter pigs, goats, and sheep in Ugandaen
dcterms.abstract<b>Introduction</b> <i>Leptospira</i> are a group of bacteria, including pathogenic types that cause leptospirosis. In Uganda, <i>Leptospira</i> exposure has been reported in humans, with domesticated animals being speculated as the source. However, comparable evidence of <i>Leptospira</i> prevalence and circulating serovars/serogroups in animals is only documented for cattle, and dogs. Our study determined <i>Leptospira</i> seroprevalence, associated risk factors and serogroups circulating among slaughtered pigs, goats, and sheep in Uganda. <b>Methods</b> During an 11-month cross-sectional survey in selected slaughter facilities in three regions of Uganda, we collected blood from 926 pigs, 347 goats, and 116 sheep. The age, sex, breed, and origin of each sampled animal were noted. The samples were tested for anti-<i>Leptospira</i> antibodies using the microscopic agglutination test, based on a panel of 12 serovars belonging to 12 serogroups. <b>Results</b> <i>Leptospira</i> seroprevalence was 26.67% (247/926, 95%CI 23.92–29.61) among pigs, and 21.81% (101/463, 95%CI 18.29–25.80) in goats and sheep (small ruminants). <i>L. interrogans</i> Australis and <i>L. kirschneri</i> Grippotyphosa were the commonest serovars among pigs, as was <i>L. borgpetersenii</i>Tarassovi in small ruminants. Pigs sourced from the Eastern (Odds Ratio [OR] = 2.82, 95%CI 1.84–4.30) and Northern (OR = 3.56, 95%CI 2.52–5.02) regions were more likely to be seropositive, compared to those from the Central region. For small ruminants, being female (OR 2.74, 95% CI 1.69–4.57) and adult (OR 4.47, 95% CI 1.57–18.80) was significantly more associated with <i>Leptospira</i> seropositivity. <b>Conclusion/significance</b> Detection of a moderate seroprevalence, and several <i>Leptospira</i> serogroups among pigs, sheep, and goats from all regions of Uganda, supports existing reports in cattle and dogs, and implies widespread <i>Leptospira</i> exposure in domestic animals in Uganda. These findings may inform future programs for the control of leptospirosis in livestock in Uganda.en
dcterms.accessRightsOpen Access
dcterms.audienceAcademicsen
dcterms.audienceScientistsen
dcterms.available2024-03-15
dcterms.bibliographicCitationAlinaitwe, L., Aturinda, C.J., Lubega, A., Kivali, V., Bugeza, J., Wainaina, M., Richter, M.H., Hoona, J.J., Roesel, K., Mayer-Scholl, A., Cook, E.A.J., Kankya, C. and Dürr, S. 2024. Cross-sectional serosurvey of <i>Leptospira</i> species among slaughter pigs, goats, and sheep in Uganda. <i>PLOS Neglected Tropical Diseases</i> 18(3): e0012055.en
dcterms.extente0012055en
dcterms.issued2024-03-15
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherPublic Library of Scienceen
dcterms.subjectzoonosesen
dcterms.subjectswineen
dcterms.subjectgoatsen
dcterms.subjectsmall ruminantsen
dcterms.subjectsheepen
dcterms.subjectanimal diseasesen
dcterms.typeJournal Article

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