Assessment of Vitamin D status and association with inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project

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cg.authorship.typesNot CGIAR international institute
cg.contributor.affiliationEmory University
cg.contributor.affiliationPennsylvania State University
cg.contributor.affiliationHospital for Sick Children, Toronto
cg.contributor.affiliationCenters for Disease Control and Prevention
cg.contributor.donorBill & Melinda Gates Foundation
cg.contributor.donorCenters for Disease Control and Prevention
cg.contributor.donorUnited States Agency for International Development
cg.contributor.donorEunice Kennedy Shriver National Institute of Child Health and Human Development
cg.contributor.donorEunice Kennedy Shriver National Institute of Child Health and Human Development
cg.coverage.countryAfghanistan
cg.coverage.countryCambodia
cg.coverage.countryPakistan
cg.coverage.countryUnited Kingdom
cg.coverage.countryUnited States
cg.coverage.countryVietnam
cg.coverage.regionAsia
cg.coverage.regionSouthern Asia
cg.coverage.regionEastern Asia
cg.coverage.regionWestern Asia
cg.coverage.regionWestern Europe
cg.coverage.regionEurope
cg.coverage.regionAmericas
cg.coverage.regionNorthern America
cg.howPublishedFormally Published
cg.identifier.doihttps://doi.org/10.1016/j.ajcnut.2022.10.018
cg.identifier.projectIFPRI - HarvestPlus
cg.identifier.publicationRankA Plus
cg.isijournalISI Journal
cg.issn1938-3207
cg.issue1
cg.journalAmerican Journal of Clinical Nutrition
cg.reviewStatusPeer Review
cg.subject.impactAreaNutrition, health and food security
cg.volume117
dc.contributor.authorYoung, Melissa F.
dc.contributor.authorOu, Jiangda
dc.contributor.authorDuong, Cam
dc.contributor.authorLuo, Hanqi
dc.contributor.authorBeyh, Yara S.
dc.contributor.authorMeng, Jiawei
dc.contributor.authorGernand, Alison D.
dc.contributor.authorRoth, Daniel E.
dc.contributor.authorSuchdev, Parminder S.
dc.date.accessioned2025-07-16T20:48:10Z
dc.date.available2025-07-16T20:48:10Z
dc.identifier.urihttps://hdl.handle.net/10568/175657
dc.titleAssessment of Vitamin D status and association with inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) projecten
dcterms.abstractBackground It is unclear whether 25(OH)D concentrations in children and female adults may be influenced by inflammation and thus require adjustment when estimating the population prevalence of vitamin D deficiency. Objectives We examined correlations between inflammation biomarkers, CRP or alpha-1-acid glycoprotein (AGP), and serum 25(OH)D concentrations among preschool children (PSC; 6–59 mo) and nonpregnant females of reproductive age (FRA; 15–49 y). Methods We analyzed cross-sectional data from 6 nationally representative nutrition surveys (Afghanistan, Cambodia, Pakistan, UK, USA, and Vietnam) conducted among PSC (n = 9880) and FRA (n = 14,749) from the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia project. Rank correlations between CRP or AGP and 25(OH)D concentrations were examined while taking into account complex survey design effects. Results Among both PSC and FRA, correlations between inflammation and vitamin D biomarkers were weak and inconsistent across surveys. For PSC, correlation coefficients between CRP and 25(OH)D concentrations ranged from −0.04 to 0.08, and correlations between AGP and 25(OH)D ranged from 0.01 to 0.05. Correlation coefficients between CRP and 25(OH)D for FRA ranged from −0.11 to 0.14, and correlations between AGP and 25(OH)D concentrations ranged from −0.05 to 0.01. Conclusions Based on the weak and inconsistent correlations between CRP or AGP and 25(OH)D, there is no rationale to adjust for these inflammation biomarkers when estimating population prevalence of vitamin D deficiency in PSC or FRA.en
dcterms.accessRightsOpen Access
dcterms.audienceAcademics
dcterms.available2022-12-21
dcterms.bibliographicCitationYoung, Melissa F.; Ou, Jiangda; Duong, Cam; Luo, Hanqi; Beyh, Yara S.; Meng, Jiawei; et al. 2023. Assessment of Vitamin D status and association with inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project. American Journal of Clinical Nutrition 117(1): 175-181. https://doi.org/10.1016/j.ajcnut.2022.10.018
dcterms.extentp. 175-181
dcterms.issued2023-01
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherElsevier
dcterms.subjectvitamin D
dcterms.subjectinflammation
dcterms.subjectbiomarkers
dcterms.subjectanaemia
dcterms.subjectwomen
dcterms.subjectchildren
dcterms.typeJournal Article

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