Genomic epidemiology of Rift Valley fever virus involved in the 2018 and 2022 outbreaks in livestock in Rwanda

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cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationSokoine University of Agricultureen
cg.contributor.affiliationRwanda Inspectorate, Competition and Consumer Protection Authorityen
cg.contributor.affiliationVirginia Polytechnic Institute and State Universityen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationRwanda Agriculture and Animal Resources Development Boarden
cg.contributor.affiliationRwanda Biomedical Centeren
cg.contributor.donorFederal Ministry for Economic Cooperation and Development, Germanyen
cg.contributor.donorRegional Scholarship and Innovation Fund of the African Partnership for Skills in Applied Sciences, Engineering, and Technologyen
cg.contributor.donorGlobal Health EDCTP3 Joint Undertakingen
cg.contributor.donorBill & Melinda Gates Foundationen
cg.contributor.donorGovernment of Rwandaen
cg.coverage.countryRwanda
cg.coverage.iso3166-alpha2RW
cg.coverage.regionAfrica
cg.coverage.regionEastern Africa
cg.creator.identifierJohn Juma: 0000-0002-1481-5337
cg.creator.identifierKristina Roesel: 0000-0002-2553-1129
cg.creator.identifierBernard Bett: 0000-0001-9376-2941
cg.creator.identifierSamuel O. Oyola: 0000-0002-6425-7345
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.3390/v16071148en
cg.isijournalISI Journalen
cg.issn1999-4915en
cg.issue7en
cg.journalVirusesen
cg.reviewStatusPeer Reviewen
cg.subject.actionAreaResilient Agrifood Systems
cg.subject.ilriLIVESTOCKen
cg.subject.ilriRVFen
cg.subject.impactAreaNutrition, health and food security
cg.subject.impactPlatformNutrition, Health and Food Security
cg.subject.sdgSDG 2 - Zero hungeren
cg.volume16en
dc.contributor.authorNsengimana, I.en
dc.contributor.authorJuma, Johnen
dc.contributor.authorRoesel, Kristinaen
dc.contributor.authorGasana, M.N.en
dc.contributor.authorNdayisenga, F.en
dc.contributor.authorMuvunyi, C.M.en
dc.contributor.authorHakizimana, E.en
dc.contributor.authorHakizimana, J.N.en
dc.contributor.authorEastwood, G.en
dc.contributor.authorChengula, A.A.en
dc.contributor.authorBett, Bernard K.en
dc.contributor.authorKasanga, C.J.en
dc.contributor.authorOyola, Samuel O.en
dc.date.accessioned2024-07-19T09:45:12Zen
dc.date.available2024-07-19T09:45:12Zen
dc.identifier.urihttps://hdl.handle.net/10568/149156
dc.titleGenomic epidemiology of Rift Valley fever virus involved in the 2018 and 2022 outbreaks in livestock in Rwandaen
dcterms.abstractRift Valley fever (RVF), a mosquito-borne transboundary zoonosis, was first confirmed in Rwanda’s livestock in 2012 and since then sporadic cases have been reported almost every year. In 2018, the country experienced its first large outbreak, which was followed by a second one in 2022. To determine the circulating virus lineages and their ancestral origin, two genome sequences from the 2018 outbreak, and thirty-six, forty-one, and thirty-eight sequences of small (S), medium (M), and large (L) genome segments, respectively, from the 2022 outbreak were generated. All of the samples from the 2022 outbreak were collected from slaughterhouses. Both maximum likelihood and Bayesian-based phylogenetic analyses were performed. The findings showed that RVF viruses belonging to a single lineage, C, were circulating during the two outbreaks, and shared a recent common ancestor with RVF viruses isolated in Uganda between 2016 and 2019, and were also linked to the 2006/2007 largest East Africa RVF outbreak reported in Kenya, Tanzania, and Somalia. Alongside the wild-type viruses, genetic evidence of the RVFV Clone 13 vaccine strain was found in slaughterhouse animals, demonstrating a possible occupational risk of exposure with unknown outcome for people working in meat-related industry. These results provide additional evidence of the ongoing wide spread of RVFV lineage C in Africa and emphasize the need for an effective national and international One Health-based collaborative approach in responding to RVF emergencies.en
dcterms.accessRightsOpen Access
dcterms.audienceAcademicsen
dcterms.audienceScientistsen
dcterms.available2024-07-17
dcterms.bibliographicCitationNsengimana, I., Juma, J., Roesel, K., Gasana, M.N., Ndayisenga, F., Muvunyi, C.M., Hakizimana, E., Hakizimana, J.N., Eastwood, G., Chengula, A.A., Bett, B., Kasanga, C.J. and Oyola, S.O. 2024. Genomic epidemiology of Rift Valley fever virus involved in the 2018 and 2022 outbreaks in livestock in Rwanda. Viruses 16(7): 1148.en
dcterms.extent1148en
dcterms.issued2024-07-17
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherMDPIen
dcterms.subjectgenomicsen
dcterms.subjectlivestocken
dcterms.subjectrift valley feveren
dcterms.typeJournal Article

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