High occurrence of mitochondrial heteroplasmy in nepalese indigenous sheep (Ovis aries) compared to chinese sheep

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cg.authorship.typesCGIAR and developing country institute
cg.contributor.affiliationChinese Academy of Agricultural Sciences
cg.contributor.affiliationNepal Agricultural Research Council
cg.contributor.affiliationInternational Livestock Research Institute
cg.contributor.crpLivestock and Fish
cg.coverage.countryChina
cg.coverage.countryNepal
cg.coverage.iso3166-alpha2CN
cg.coverage.iso3166-alpha2NP
cg.coverage.regionAsia
cg.coverage.regionSouthern Asia
cg.coverage.regionEastern Asia
cg.howPublishedFormally Published
cg.identifier.doihttps://doi.org/10.3109/19401736.2015.1041134
cg.isijournalISI Journal
cg.issn2470-1394
cg.issue4
cg.journalMitochondrial DNA
cg.reviewStatusPeer Review
cg.subject.ilriINDIGENOUS BREEDS
cg.subject.ilriRESEARCH
cg.subject.ilriSHEEP
cg.volume27
dc.contributor.authorGorkhali, N.A.
dc.contributor.authorLin Jiang
dc.contributor.authorShrestha, B.S.
dc.contributor.authorXiao-Hong He
dc.contributor.authorQian-Jun Zhao
dc.contributor.authorHan Jianlin
dc.contributor.authorYue-Hui Ma
dc.date.accessioned2016-03-06T15:53:49Zen
dc.date.available2016-03-06T15:53:49Zen
dc.identifier.urihttps://hdl.handle.net/10568/72466
dc.titleHigh occurrence of mitochondrial heteroplasmy in nepalese indigenous sheep (Ovis aries) compared to chinese sheepen
dcterms.abstractHeteroplasmy due to length polymorphism with tandem repeats in mtDNAs within individual was hardly studied in domestic animals. In the present study, we identified intra-individual length variation in the control region of mtDNAs in Nepalese sheep by molecular cloning and sequencing techniques. We observed one to four tandem repeats of a 75-bp nucleotide sequences in the mtDNA control region in 45% of the total Nepalese sheep sampled in contrast to the Chinese sheep, indicating that the heteroplasmy is specific to Nepalese sheep. The high rate of heteroplasmy in Nepalese sheep could be a resultant of the mtDNA mutation and independent segregation at intra-individual level or a strand slippage and mispairing during the replication.en
dcterms.accessRightsLimited Access
dcterms.audienceScientists
dcterms.available2015-06-18
dcterms.bibliographicCitationGorkhali, N.A., Lin Jiang, Shrestha, B.S., Xiao-Hong He, Qian Junzhao, Jian-Lin Han and Yue-Hui Ma. 2015. High occurrence of mitochondrial heteroplasmy in nepalese indigenous sheep (Ovis aries) compared to chinese sheep. Mitochondrial DNA 18: 1-3.en
dcterms.extentp. 2645-2647
dcterms.issued2016-07-03
dcterms.languageen
dcterms.publisherInforma UK Limited
dcterms.subjectsheepen
dcterms.subjectindigenous breedsen
dcterms.subjectresearchen
dcterms.typeJournal Article

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