Effects of aflatoxins and fumonisins, alone or in combination, on performance, health, and safety of food products of broiler chickens, and mitigation efficacy of bentonite and fumonisin esterase

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cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationUniversity of Liègeen
cg.contributor.affiliationGhent Universityen
cg.contributor.affiliationChuka Universityen
cg.contributor.affiliationUniversity of Nairobien
cg.contributor.affiliationDSM - BIOMIN Research Centeren
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationUppsala Universityen
cg.contributor.affiliationSwedish University of Agricultural Sciencesen
cg.contributor.donorMinistry of Education, Science and Technology, Kenyaen
cg.contributor.donorBelgian National Fund for Scientific Researchen
cg.contributor.donorBelgian Science Policy Officeen
cg.contributor.donorHarbro Ltd.en
cg.contributor.donorResearch Council of Norwayen
cg.contributor.donorNational Research Foundation, South Africaen
cg.contributor.donorBIOMIN Holding GmbHen
cg.coverage.regionAfrica
cg.coverage.regionSub-Saharan Africa
cg.creator.identifierJohanna Lindahl: 0000-0002-1175-0398
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1021/acs.jafc.3c01733en
cg.isijournalISI Journalen
cg.issn0021-8561en
cg.issue36en
cg.journalJournal of Agricultural and Food Chemistryen
cg.reviewStatusPeer Reviewen
cg.subject.ilriAFLATOXINSen
cg.subject.ilriCHICKENSen
cg.subject.ilriFEEDSen
cg.subject.ilriFOOD SAFETYen
cg.subject.ilriPOULTRYen
cg.subject.impactAreaNutrition, health and food security
cg.subject.sdgSDG 3 - Good health and well-beingen
cg.volume71en
dc.contributor.authorOchieng, P.E.en
dc.contributor.authorCroubels, S.en
dc.contributor.authorKemboi, D.en
dc.contributor.authorOkoth, S.en
dc.contributor.authorBaere, S. deen
dc.contributor.authorCavalier, E.en
dc.contributor.authorKang'ethe, Erastus K.en
dc.contributor.authorFaas, J.en
dc.contributor.authorDoupovec, B.en
dc.contributor.authorGathumbi, J.en
dc.contributor.authorDouny, C.en
dc.contributor.authorScippo, M.-L.en
dc.contributor.authorLindahl, Johanna F.en
dc.contributor.authorAntonissen, G.en
dc.date.accessioned2023-09-05T07:56:00Zen
dc.date.available2023-09-05T07:56:00Zen
dc.identifier.urihttps://hdl.handle.net/10568/131736
dc.titleEffects of aflatoxins and fumonisins, alone or in combination, on performance, health, and safety of food products of broiler chickens, and mitigation efficacy of bentonite and fumonisin esteraseen
dcterms.abstractThe current study evaluated the effects of feeding diets contaminated with aflatoxin B1 (AFB1), fumonisins (FBs), or both on the performance and health of broiler chickens and the safety of their food products as well as the efficacy of bentonite and fumonisin esterase to mitigate the effects of these mycotoxins under conditions representative for sub-Saharan Africa (SSA). Four hundred one-day-old Cobb 500 broiler chickens were randomly assigned to 20 treatments with either a control diet, a diet with moderate AFB1 (60 μg/kg feed) or high AFB1 (220 μg/kg feed), or FBs (17,430 μg FB1+FB2/kg feed), alone or in combination, a diet containing AFB1 (either 60 or 220 μg/kg) and/or FBs (17,430 μg FB1+FB2/kg) and bentonite or fumonisin esterase or both, or a diet with bentonite or fumonisin esterase only. The experimental diets were given to the birds from day 1 to day 35 of age, and the effects of the different treatments on production performance were assessed by feed intake (FI), body weight gain (BWG), and feed conversion ratio (FCR). Possible health effects were evaluated through blood biochemistry, organ weights, mortality, liver gross pathological changes, and vaccine response. Residues of aflatoxins (AFB1, B2, G1, G2, M1 and M2) were determined in plasma, muscle, and liver tissues using validated UHPLC-MS/MS methods. The results obtained indicated that broiler chickens fed high AFB1 alone had poor FCR when compared to a diet with both high AFB1 and FBs (p = 0.0063). Serum total protein and albumin from birds fed FBs only or in combination with moderate or high AFB1 or detoxifiers increased when compared to the control (p < 0.05). Liver gross pathological changes were more pronounced in birds fed contaminated diets when compared to birds fed the control or diets supplemented with mycotoxin detoxifiers. The relative weight of the heart was significantly higher in birds fed high AFB1 and FBs when compared to the control or high AFB1 only diets (p < 0.05), indicating interactions between the mycotoxins. Inclusion of bentonite in AFB1-contaminated diets offered a protective effect on the change in weights of the liver, heart and spleen (p < 0.05). Residues of AFB1 were detected above the limit of quantification (max: 0.12 ± 0.03 μg/kg) in liver samples only, from birds fed a diet with high AFB1 only or with FBs or the detoxifiers. Supplementing bentonite into these AFB1-contaminated diets reduced the levels of the liver AFB1 residues by up to 50%. Bentonite or fumonisin esterase, alone, did not affect the performance and health of broiler chickens. Thus, at the doses tested, both detoxifiers were safe and efficient for use as valid means of counteracting the negative effects of AFB1 and FBs as well as transfer of AFB1 to food products (liver) of broiler chickens.en
dcterms.accessRightsLimited Access
dcterms.audienceAcademicsen
dcterms.audienceScientistsen
dcterms.available2023-09-01
dcterms.bibliographicCitationOchieng, P.E., Croubels, S., Kemboi, D., Okoth, S., De Baere, S., Cavalier, E., Kang'ethe, E., Faas, J., Doupovec, B., Gathumbi, J., Douny, C., Scippo, M.-L., Lindahl, J.F. and Antonissen, G. 2023. Effects of aflatoxins and fumonisins, alone or in combination, on performance, health, and safety of food products of broiler chickens, and mitigation efficacy of bentonite and fumonisin esterase. Journal of Agricultural and Food Chemistry 71(36): 13462–13473.en
dcterms.extent13462–13473en
dcterms.issued2023-09-01
dcterms.languageen
dcterms.licenseCopyrighted; all rights reserved
dcterms.publisherAmerican Chemical Societyen
dcterms.subjectaflatoxinsen
dcterms.subjectfood safetyen
dcterms.subjectfumonisinsen
dcterms.subjectbentoniteen
dcterms.subjectfeedsen
dcterms.subjectpoultryen
dcterms.subjectchickensen
dcterms.typeJournal Article

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