The effect of zinc-biofortified rice on zinc status of Bangladeshi pre-school children: A randomized, double-masked, household-based controlled trial
| cg.authorship.types | CGIAR and developing country institute | en |
| cg.contributor.crp | Agriculture for Nutrition and Health | |
| cg.contributor.donor | Foreign, Commonwealth and Development Office, United Kingdom | en |
| cg.contributor.donor | Bill & Melinda Gates Foundation | en |
| cg.contributor.donor | Government of Canada | en |
| cg.contributor.donor | European Union | en |
| cg.contributor.donor | John D. and Catherine T. MacArthur Foundation | en |
| cg.contributor.donor | CGIAR Trust Fund | en |
| cg.coverage.country | Bangladesh | |
| cg.coverage.iso3166-alpha2 | BD | |
| cg.coverage.region | Southern Asia | |
| cg.coverage.region | Asia | |
| cg.identifier.doi | https://doi.org/10.1093/ajcn/nqab379 | en |
| cg.identifier.project | IFPRI - HarvestPlus | |
| cg.identifier.project | IFPRI - Feed the Future | |
| cg.isijournal | ISI Journal | en |
| cg.issn | 0002-9165 | en |
| cg.issue | 3 | en |
| cg.journal | American Journal of Clinical Nutrition | en |
| cg.reviewStatus | Peer Review | en |
| cg.volume | 115 | en |
| dc.contributor.author | Jongstra, Roelinda | en |
| dc.contributor.author | Mokbul Hossain, Md | en |
| dc.contributor.author | Galetti, Valeria | en |
| dc.contributor.author | Hall, Andrew G. | en |
| dc.contributor.author | Holt, Roberta R. | en |
| dc.date.accessioned | 2025-01-29T12:58:14Z | en |
| dc.date.available | 2025-01-29T12:58:14Z | en |
| dc.identifier.uri | https://hdl.handle.net/10568/171480 | |
| dc.title | The effect of zinc-biofortified rice on zinc status of Bangladeshi pre-school children: A randomized, double-masked, household-based controlled trial | en |
| dcterms.abstract | Background: Zinc biofortification of rice could sustainably improve zinc status in countries where zinc deficiency is common and rice is a staple, but its efficacy has not been tested. Fatty acid desaturases (FADS) are putative new zinc status biomarkers. Objective: Our objective was to test the efficacy of zinc-biofortified rice in preschool-aged children with zinc-deficiency. Our hypothesis was that consumption of zinc-biofortified rice would increase plasma zinc concentration (PZC). Design: We conducted a 9-month, double-masked, intervention trial in 12–36 month-old rural Bangladeshi children, most of whem were who were zinc-deficient (PZC < 70 µg/dL) and stunted (n = 520). The children were randomized to receive either control rice (CR) or zinc-biofortified rice (BFR) provided in cooked portions to their households daily, with compliance monitoring. The primary outcome was PZC. Secondary outcomes were zinc deficiency, linear growth, infection-related morbidity, FADS activity indices, intestinal fatty acid binding protein (I-FABP) and fecal calprotectin. We applied sparse serial sampling for midpoint measures and analyzed data by intention-to-treat using mixed-effects models. The trial was registered under NCT03079583. Results: At baseline, median (IQR) PZC was 60.4 (56.3–64.3) µg/dL, 78.1% of children were zinc deficient and 59.7% were stunted. Mean ± SD daily zinc intakes from the CR and BFR during the trial were 1.20 ± 0.34 and 2.22 ± 0.47 mg/day, respectively (P < 0.001). There were no significant time-by-treatment effects on PZC, zinc deficiency prevalence, FADS activity, I-FABP or fecal calprotectin (all P > 0.05). There was a time-treatment interaction for height-for-age z scores (P < 0.001) favoring the BFR group. The morbidity longitudinal prevalence ratio (LPR) (95% CI) was 1.08 (1.05,1.12) comparing the BFR and CR groups, due to more upper respiratory tract illness in the BFR group. Conclusions: Consumption of zinc-biofortified rice for 9 months providing ∼1 mg of additional zinc daily to Bangladeshi children did not significantly affect PZC, prevalence of zinc deficiency or FADS activity. Clinical Trial Registry: https://clinicaltrials.gov/ct2/show/NCT03079583 | en |
| dcterms.accessRights | Open Access | |
| dcterms.bibliographicCitation | Jongstra, Roelinda; Mokbul Hossain, Md; Galetti, Valeria; Hall, Andrew G.; Holt, Roberta R.; et al. 2022. The effect of zinc-biofortified rice on zinc status of Bangladeshi pre-school children: A randomized, double-masked, household-based controlled trial. American Journal of Clinical Nutrition 115(3): 724-737. https://doi.org/10.1093/ajcn/nqab379 | en |
| dcterms.extent | pp. 724-737 | en |
| dcterms.issued | 2022-03 | |
| dcterms.language | en | |
| dcterms.license | CC-BY-4.0 | |
| dcterms.publisher | American Society for Nutrition | en |
| dcterms.subject | zinc | en |
| dcterms.subject | biofortification | en |
| dcterms.subject | schoolchildren | en |
| dcterms.subject | children | en |
| dcterms.subject | rice | en |
| dcterms.subject | trace elements | en |
| dcterms.type | Journal Article |