Evidence of balanced diversity at the chicken interleukin 4 receptor alpha chain locus

Downing, T.; Lynn, D.J.; Connell, S.; Lloyd, A.T.; Bhuiyan, A.K.F.H.; Silva, P.; Naqvi, A.N.; Sanfo, R.; Sow, R-S.; Podisi, B.; Hanotte, O.; O'Farelly, C.O.; Bradley, D. 2009. Evidence of balanced diversity at the chicken interleukin 4 receptor alpha chain locus. BMC Evolutionary Biology. 9:136-149.

The comparative analysis of genome sequences emerging for several avian species with the fully sequenced chicken genome enables the genome-wide investigation of selective processes in functionally important chicken genes. In particular, because of pathogenic challenges it is expected that genes involved in the chicken immune system are subject to particularly strong adaptive pressure. Signatures of selection detected by inter-species comparison may then be investigated at the population level in global chicken populations to highlight potentially relevant functional polymorphisms.