Haplotype-resolved genome assembly of Musella lasiocarpa reveals the critical role of structural variations in chromosomal and genome evolution

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cg.authorship.typesCGIAR and advanced research institute
cg.contributor.affiliationBioversity International
cg.contributor.affiliationSouth China Botanical Garden
cg.contributor.initiativeGenebanks
cg.contributor.programAcceleratorGenebanks
cg.coverage.countryChina
cg.coverage.iso3166-alpha2CN
cg.coverage.regionAsia
cg.coverage.regionEastern Asia
cg.creator.identifierQing Liu: 0000-0003-2712-6028
cg.creator.identifierDongli Cui: 0000-0003-0254-1364
cg.creator.identifierWang, Yehan: 0009-0003-4075-3162
cg.creator.identifierMathieu Rouard: 0000-0003-0284-1885
cg.creator.identifierJS Heslop-Harrison: 0000-0002-3105-2167
cg.creator.identifierTrude Schwarzacher: 0000-0001-8310-5489
cg.creator.identifierZiwei Wang: 0000-0002-5590-2437
cg.identifier.doihttps://doi.org/10.1016/j.ygeno.2026.111210
cg.isijournalISI Journal
cg.issn0888-7543
cg.issue2
cg.journalGenomics
cg.number111210
cg.reviewStatusPeer Review
cg.subject.alliancebiovciatBANANA
cg.subject.alliancebiovciatCROP WILD RELATIVES
cg.volume118
dc.contributor.authorLiu, Qing
dc.contributor.authorCui, Dongli
dc.contributor.authorTian, Yaqi
dc.contributor.authorWang, Yehan
dc.contributor.authorRouard, Mathieu
dc.contributor.authorHeslop-Harrison, John Seymour
dc.contributor.authorSchwarzacher, Trude
dc.contributor.authorWang, Ziwei
dc.date.accessioned2026-02-05T11:56:35Z
dc.date.available2026-02-05T11:56:35Z
dc.identifier.urihttps://hdl.handle.net/10568/181214
dc.titleHaplotype-resolved genome assembly of Musella lasiocarpa reveals the critical role of structural variations in chromosomal and genome evolutionen
dcterms.abstractMusella lasiocarpa (MLA, 2n = 18, Musaceae) is an endangered species native to south-western China. We assembled its haplotype-resolved, telomere-to-telomere genomes with a genome size of 503.6 Mb consisting of 52.8% repetitive DNA. A 134 bp tandem repeat, Mlcen, was identified at all centromeres, and telomere sequences were present at 30 of 36 assembled pseudo-chromosome ends. The distal gene-rich regions display high synteny, whereas retrotransposon polymorphisms between haplotypes occurred throughout chromosomes, contributing to diversity. Phylogenetic analysis shows MLA diverged from Ensete 42 million years ago, and together they share a common ancestor with Musa. Among 35,312 protein-coding genes, 14 up-regulated and 34 down-regulated transcription factors were identified under cold treatment. This high-quality genomic resource advances our understanding of MLA chromosomal evolution characterized by structural variations, repetitive DNA dynamics, and cold-responsive genes at both haplotype and species levels; and enables genome-assisted improvement of more resilient crops such as bananas and Ensete.en
dcterms.accessRightsOpen Access
dcterms.available2026-01-27
dcterms.bibliographicCitationLiu, Q.; Cui, D.; Tian, Y.; Wang, Y.; Rouard, M.; Heslop-Harrison, J.S.; Schwarzacher, T.; Wang, Z. (2026) Haplotype-resolved genome assembly of Musella lasiocarpa reveals the critical role of structural variations in chromosomal and genome evolution. Genomics 118(2): 111210. ISSN: 0888-7543en
dcterms.issued2026-03
dcterms.languageen
dcterms.licenseCC-BY-NC-ND-4.0
dcterms.publisherElsevier
dcterms.subjectclimate change adaptationen
dcterms.subjectmusaceaeen
dcterms.subjectstructural adjustmenten
dcterms.subjectgenomeen
dcterms.typeJournal Article

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