Chromosome-level genome assembly of the Muscovy duck provides insight into fatty liver susceptibility

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cg.authorship.typesCGIAR and developing country institute
cg.contributor.affiliationChinese Academy of Sciences
cg.contributor.affiliationUniversity of Chinese Academy of Sciences
cg.contributor.affiliationHainan Academy of Agricultural Sciences
cg.contributor.affiliationYunnan University
cg.contributor.affiliationNowbio Biotechnology Company, China
cg.contributor.affiliationZhejiang Academy of Agricultural Sciences
cg.contributor.affiliationChina Agricultural University
cg.contributor.affiliationYunnan Agricultural University
cg.contributor.affiliationChinese Academy of Agricultural Sciences
cg.contributor.affiliationInternational Livestock Research Institute
cg.contributor.affiliationChinese Academy of Tropical Agricultural Sciences
cg.contributor.donorChinese Academy of Sciences
cg.coverage.countryChina
cg.coverage.iso3166-alpha2CN
cg.coverage.regionAsia
cg.coverage.regionEastern Asia
cg.howPublishedFormally Published
cg.identifier.doihttps://doi.org/10.1016/j.ygeno.2022.110518
cg.isijournalISI Journal
cg.issn1089-8646
cg.issue6
cg.journalGenomics
cg.number110518
cg.reviewStatusPeer Review
cg.subject.ilriANIMAL BREEDING
cg.subject.ilriCHICKENS
cg.subject.ilriGENETICS
cg.subject.ilriPOULTRY
cg.volume114
dc.contributor.authorXu, Ming-Min
dc.contributor.authorGu, Li-Hong
dc.contributor.authorLv, Wan-Yue
dc.contributor.authorDuan, Sheng-Chang
dc.contributor.authorLi, Lian-Wei
dc.contributor.authorDu, Yuan
dc.contributor.authorLu, Li-Zhi
dc.contributor.authorZeng, Tao
dc.contributor.authorHou, Zhuo-Cheng
dc.contributor.authorMa, Zhanshan Sam
dc.contributor.authorChen, Wei
dc.contributor.authorAdeola, A.C.
dc.contributor.authorHan Jianlin
dc.contributor.authorXu, Tie-Shan
dc.contributor.authorDong, Yang
dc.contributor.authorZhang, Ya-Ping
dc.contributor.authorPeng, Min-Sheng
dc.date.accessioned2022-11-12T17:07:06Zen
dc.date.available2022-11-12T17:07:06Zen
dc.identifier.urihttps://hdl.handle.net/10568/125431
dc.titleChromosome-level genome assembly of the Muscovy duck provides insight into fatty liver susceptibilityen
dcterms.abstractThe Muscovy duck (Cairina moschata) is an economically important poultry species, which is susceptible to fatty liver. Thus, the Muscovy duck may serve as an excellent candidate animal model of non-alcoholic fatty liver disease. However, the mechanisms underlying fatty liver development in this species are poorly understood. In this study, we report a chromosome-level genome assembly of the Muscovy duck, with a contig N50 of 11.8 Mb and scaffold N50 of 83.16 Mb. The susceptibility of Muscovy duck to fatty liver was mainly attributed to weak lipid catabolism capabilities (fatty acid β-oxidation and lipolysis). Furthermore, conserved noncoding elements (CNEs) showing accelerated evolution contributed to fatty liver formation by down-regulating the expression of genes involved in hepatic lipid catabolism. We propose that the susceptibility of Muscovy duck to fatty liver is an evolutionary by-product. In conclusion, this study revealed the potential mechanisms underlying the susceptibility of Muscovy duck to fatty liver.en
dcterms.accessRightsOpen Access
dcterms.audienceScientists
dcterms.bibliographicCitationXu, Ming-Min, Gu, Li-Hong, Lv, Wan-Yue, Duan, Sheng-Chang, Li, Lian-Wei, Du, Yuan, Lu, Li-Zhi, Zeng, Tao, Hou, Zhuo-Cheng, Ma, Zhanshan Sam, Chen, Wei, Adeola, A.C., Jian-Lin, Han, Xu, Tie-Shan, Dong, Yang, Zhang, Ya-Ping and Peng, Min-Sheng. 2022. Chromosome-level genome assembly of the Muscovy duck provides insight into fatty liver susceptibility. Genomics 114(6):110518.en
dcterms.issued2022-11
dcterms.languageen
dcterms.licenseCC-BY-NC-ND-4.0
dcterms.publisherElsevier
dcterms.subjectgeneticsen
dcterms.subjectanimal breedingen
dcterms.subjectduck breedsen
dcterms.subjectfatty liveren
dcterms.subjectmuscovy ducksen
dcterms.typeJournal Article

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