Drought-induced cyanogenesis in sorghum (Sorghum bicolor L.): Genotypic variation in dhurrin biosynthesis and stress response

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cg.authorship.typesCGIAR and developing country institute
cg.authorship.typesCGIAR and advanced research institute
cg.contributor.affiliationInternational Crops Research Institute for the Semi-Arid Tropics
cg.contributor.affiliationOsmania University
cg.contributor.affiliationIndian Institute of Science Education and Research
cg.contributor.affiliationInternational Livestock Research Institute
cg.contributor.affiliationAlliance of Biodiversity International and the International Center for Tropical Agriculture
cg.contributor.affiliationCzech University of Life Sciences Prague
cg.contributor.affiliationInternational Atomic Energy Agency
cg.contributor.donorGovernment of India
cg.contributor.donorCzech University of Life Sciences Prague
cg.creator.identifierPrasad KVSV: 0000-0003-3672-779X
cg.creator.identifierPadmakumar Varijakshapanicker: 0000-0003-2916-3746
cg.howPublishedFormally Published
cg.identifier.doihttps://doi.org/10.1111/pce.15536
cg.isijournalISI Journal
cg.issn0140-7791
cg.journalPlant, Cell & Environment
cg.reviewStatusPeer Review
cg.speciesSorghum bicolor
cg.subject.ilriCROPS
cg.subject.impactAreaNutrition, health and food security
cg.subject.sdgSDG 2 - Zero hunger
dc.contributor.authorKatamreddy, S.C.
dc.contributor.authorJose, J.
dc.contributor.authorReddy, B.P.
dc.contributor.authorSivasakthi, K.
dc.contributor.authorSanivarapu, H.
dc.contributor.authorDube, N.
dc.contributor.authorGaddameedi, A.
dc.contributor.authorPrasad, Kodukula V.S.V.
dc.contributor.authorYogendra, K.
dc.contributor.authorGovindaraj, M.
dc.contributor.authorKholova, J.
dc.contributor.authorChoudhury, S.R.
dc.contributor.authorKavi Kishor, P.B.
dc.contributor.authorVarijakshapanicker, Padmakumar
dc.contributor.authorBhatnagar-Mathur, P.
dc.contributor.authorAre, A.K.
dc.contributor.authorReddy, P.S.
dc.date.accessioned2025-07-09T04:33:49Z
dc.date.available2025-07-09T04:33:49Z
dc.identifier.urihttps://hdl.handle.net/10568/175549
dc.titleDrought-induced cyanogenesis in sorghum (Sorghum bicolor L.): Genotypic variation in dhurrin biosynthesis and stress responseen
dcterms.abstractThe accumulation of the livestock-harming cyanogenic glucoside dhurrin in the vegetative tissues limits the use of sorghum as a major pasture crop. This study integrates transcriptomics and metabolomics data from the ICSV 93046, CSH 24-MF and ICSR 14001 genotypes, which differ in drought tolerance and cyanide potential (HCNp), to understand the molecular processes of cyanogenesis under drought stress conditions. While ICSV 93046 showed drought adaptation and reduced HCNp, ICSR 14001 and CSH 24-MF exhibited decreased drought stress tolerance with HCN accumulation. The differentially expressed gene (DEG) data showed drought-related genes were significantly upregulated in ICSV 93046 but downregulated in ICSR 14001. KEGG pathway analysis revealed enriched dhurrin biosynthesis and cyanoamino acid metabolism genes, with higher expression in ICSR 14001 than in ICSV 93046. WGCNA analysis revealed that hub genes are involved in drought-induced signalling components, such as phospholipases (PLPs) and lipoxygenases (LOXs), which are implicated in membrane protection. In drought-sensitive genotypes, stress-induced membrane damages lead to the release of dhurrin into the cytoplasm, thus elevating HCN content and activating defence responses. Conversely, the drought-adapted genotype could mitigate HCN production by averting membrane injury, thereby effectively modulating the oxidative stress and preventing the release of dhurrin into the cytoplasm.en
dcterms.accessRightsLimited Access
dcterms.audienceAcademics
dcterms.audienceScientists
dcterms.available2025-04-11
dcterms.bibliographicCitationKatamreddy, S.C., Jose, J., Reddy, B.P., Sivasakthi, K., Sanivarapu, H., Dube, N., Gaddameedi, A., Prasad, K.V.S.V., Yogendra, K., Govindaraj, M., Kholova, J., Choudhury, S.R., Kavi Kishor, P.B., Varijakshapanicker, P., Bhatnagar-Mathur, P., Are, A.K. and Reddy, P.S. 2025. Drought-induced cyanogenesis in sorghum (<i>Sorghum bicolor</i> L.): Genotypic variation in dhurrin biosynthesis and stress response. Plant, Cell & Environment.
dcterms.issued2025
dcterms.languageen
dcterms.licenseOther
dcterms.publisherWiley
dcterms.subjectcrops
dcterms.subjectsorghum
dcterms.typeJournal Article

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