MIB–MIP is a mycoplasma system that captures and cleaves immunoglobulin G

Simple item page
cg.contributor.affiliationBiologie du Fruit et Pathologie
cg.contributor.affiliationCentre national de la recherche scientifique, France
cg.contributor.affiliationInstitut Bergonié
cg.contributor.affiliationInstitut de Biologie Structurale
cg.contributor.affiliationInstitut Européen de Chimie et Biologie
cg.contributor.affiliationInternational Livestock Research Institute
cg.contributor.affiliationJ. Craig Venter Institute
cg.contributor.affiliationNormandie Université
cg.contributor.affiliationUniversity of Bern
cg.contributor.affiliationUniversity of Bordeaux
cg.contributor.donorAgence Nationale de la Recherche, France
cg.contributor.donorAtomic Energy and Alternative Energies Commission
cg.contributor.donorDirectorate for Biological Sciences
cg.contributor.donorCentre national de la recherche scientifique, France
cg.contributor.donorInserm
cg.creator.identifierJoerg Jores: 0000-0003-3790-5746
cg.identifier.doihttps://doi.org/10.1073/pnas.1600546113
cg.issn0027-8424
cg.issn1091-6490
cg.issue19
cg.journalProceedings of the National Academy of Sciences of the United States of America
cg.subject.ilriANIMAL DISEASES
cg.volume113
dc.contributor.authorArfi, Yonathan
dc.contributor.authorMinder, Laetitia
dc.contributor.authorPrimo, Carmelo di
dc.contributor.authorLe Roy, Aline
dc.contributor.authorEbel, Christine
dc.contributor.authorCoquet, Laurent
dc.contributor.authorClaverol, Stephane
dc.contributor.authorVashee, Sanjay
dc.contributor.authorJores, Joerg
dc.contributor.authorBlanchard, Alain
dc.contributor.authorSirand-Pugnet, Pascal
dc.date.accessioned2023-03-10T14:36:35Zen
dc.date.available2023-03-10T14:36:35Zen
dc.identifier.urihttps://hdl.handle.net/10568/129486
dc.titleMIB–MIP is a mycoplasma system that captures and cleaves immunoglobulin Gen
dcterms.abstractMycoplasmas are minimal pathogenic bacteria able to infect humans and a wide range of economically important animals; as such, they are major causes of concern in the medical and veterinary fields. These pathogens often lead to chronic infections, and their mechanisms of immunity evasion are poorly known. Here we describe a two-protein system from the ruminant pathogenMycoplasma mycoidessubspeciescaprithat is involved in the capture and cleavage of antibodies. MIB is able to capture the antibodies and to subsequently recruit MIP, a protease that is able to cleave the antibody heavy chain. The MIB–MIP system appears to be widespread among pathogenic mycoplasmas and is potentially a key player for the virulence and immunity evasion mechanisms of these bacteria.en
dcterms.accessRightsOpen Access
dcterms.available2016-04-25
dcterms.bibliographicCitationArfi, Yonathan; Minder, Laetitia; Primo, Carmelo di; Le Roy, Aline; Ebel, Christine; Coquet, Laurent; Claverol, Stephane; Vashee, Sanjay; Jores, Joerg; Blanchard, Alain; Sirand-Pugnet, Pascal. 2016. MIB-MIP is a mycoplasma system that captures and cleaves immunoglobulin G. Proceedings of the National Academy of Sciences 113: 5406-5411en
dcterms.extentp. 5406-5411
dcterms.issued2016-05-10
dcterms.languageen
dcterms.licenseCopyrighted; all rights reserved
dcterms.publisherNational Academy of Sciences
dcterms.subjectmycoplasmaen
dcterms.subjectsystemen
dcterms.typeJournal Article

Files

Collections

ILRI articles in journals