Molecular prevalence and risk factors associated with tick-borne pathogens in cattle in western Kenya

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cg.authorship.typesCGIAR and developing country institute
cg.authorship.typesCGIAR and advanced research institute
cg.contributor.affiliationInternational Centre of Insect Physiology and Ecology
cg.contributor.affiliationUniversity of Pretoria
cg.contributor.affiliationInternational Livestock Research Institute
cg.contributor.affiliationUniversity of Liverpool
cg.contributor.crpAgriculture for Nutrition and Health
cg.contributor.donorBiotechnology and Biological Sciences Research Council, United Kingdom
cg.contributor.donorGovernment of the United Kingdom
cg.contributor.donorEconomic and Social Research Council, United Kingdom
cg.contributor.donorMedical Research Council, United Kingdom
cg.contributor.donorNatural Environment Research Council, United Kingdom
cg.contributor.donorDefence Science and Technology Laboratory, United Kingdom
cg.contributor.donorEuropean Union
cg.contributor.donorSwedish International Development Cooperation Agency
cg.contributor.donorSwiss Agency for Development and Cooperation
cg.contributor.donorGovernment of Ethiopia
cg.contributor.donorGovernment of Kenya
cg.contributor.donorDeutscher Akademischer Austauschdienst
cg.coverage.countryKenya
cg.coverage.iso3166-alpha2KE
cg.coverage.regionAfrica
cg.coverage.regionEastern Africa
cg.creator.identifierEric M. Fèvre: 0000-0001-8931-4986
cg.creator.identifierLaura Cristina Falzon: 0000-0002-4043-1644
cg.creator.identifierDaniel Masiga: 0000-0001-7513-0887
cg.creator.identifierMaurice Murungi: 0000-0001-6467-4352
cg.creator.identifierLillian Wambua: 0000-0003-3632-7411
cg.howPublishedFormally Published
cg.identifier.doihttps://doi.org/10.1186/s12917-021-03074-7
cg.isijournalISI Journal
cg.issn1746-6148
cg.issue1
cg.journalBMC Veterinary Research
cg.number363
cg.reviewStatusPeer Review
cg.subject.ilriANIMAL DISEASES
cg.subject.ilriCATTLE
cg.subject.ilriLIVESTOCK
cg.subject.sdgSDG 2 - Zero hunger
cg.volume17
dc.contributor.authorChiuya, T.
dc.contributor.authorVillinger, J.
dc.contributor.authorMasiga, D.K.
dc.contributor.authorOndifu, D.O.
dc.contributor.authorMurungi, Maurice K.
dc.contributor.authorWambua, Lillian
dc.contributor.authorBastos, A.D.S.
dc.contributor.authorFèvre, Eric M.
dc.contributor.authorFalzon, Laura C.
dc.date.accessioned2021-11-30T07:09:34Zen
dc.date.available2021-11-30T07:09:34Zen
dc.identifier.urihttps://hdl.handle.net/10568/116387
dc.titleMolecular prevalence and risk factors associated with tick-borne pathogens in cattle in western Kenyaen
dcterms.abstractBackground Tick-borne pathogens (TBPs) are of global importance, especially in sub-Saharan Africa where they represent a major constraint to livestock production. Their association with human disease is also increasingly recognized, signalling their zoonotic importance. It is therefore crucial to investigate TBPs prevalence in livestock populations and the factors associated with their presence. We set out to identify TBPs present in cattle and to determine associated risk factors in western Kenya, where smallholder livestock production is important for subsistence and market-driven income. Results Tick-borne pathogen infections in blood samples collected from cattle at livestock markets and slaughterhouses between May 2017 and January 2019 were identified by high-resolution melting analysis and sequencing of PCR products of genus-specific primers. Of the 422 cattle sampled, 30.1% (127/422) were infected with at least one TBP, while 8.8% (37/422) had dual infections. Anaplasma spp. (19.7%) were the most prevalent, followed by Theileria (12.3%), Ehrlichia (6.6%), and Babesia (0.2%) spp. Sequence analysis of the TBPs revealed them to be Anaplasma platys-like organisms (13.5%), Theileria velifera (7.4%), Anaplasma marginale (4.9%), Theileria mutans (3.1%), Theileria parva (1.6%), and Babesia bigemina (0.2%). Ehrlichia ruminantium, Rickettsia spp., and arboviruses were not detected. Exotic breeds of cattle were more likely to be infected with A. marginale compared to local breeds (OR: 7.99, 95% CI: 3.04–22.02, p < 0.001). Presence of ticks was a significant predictor for Anaplasma spp. (OR: 2.18, 95% CI: 1.32–3.69, p = 0.003) and Ehrlichia spp. (OR: 2.79, 95% CI: 1.22–7.23, p = 0.022) infection. Cattle sampled at slaughterhouses were more likely to be positive for Anaplasma spp. (OR: 1.64, 95% CI: 1.01–2.70, p = 0.048) and A. marginale (OR: 3.84, 95% CI: 1.43–12.21, p = 0.012), compared to those sampled at livestock markets. Conclusion This study reports TBP prevalence and associated risk factors in western Kenya, factors which are key to informing surveillance and control measures.en
dcterms.accessRightsOpen Access
dcterms.audienceAcademics
dcterms.audienceScientists
dcterms.available2021-11-27
dcterms.bibliographicCitationChiuya, T., Villinger, J., Masiga, D.K., Ondifu, D.O., Murungi, M.K., Wambua, L., Bastos, A.D.S., Fèvre, E.M. and Falzon, L.C. 2021. Molecular prevalence and risk factors associated with tick-borne pathogens in cattle in western Kenya. BMC Veterinary Research 17: 363.en
dcterms.issued2021-12
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherSpringer
dcterms.subjectcattleen
dcterms.subjectpathogensen
dcterms.subjectanimal diseasesen
dcterms.typeJournal Article

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