Highly sensitive molecular assay based on Identical Multi-Repeat Sequence (IMRS) algorithm for the detection of Trichomonas vaginalis infection

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cg.authorship.typesCGIAR and developing country institute
cg.authorship.typesCGIAR and advanced research institute
cg.contributor.affiliationMount Kenya University
cg.contributor.affiliationJigsaw Bio Solutions Private Limited
cg.contributor.affiliationInternational Livestock Research Institute
cg.contributor.affiliationStockholm University
cg.contributor.affiliationBoston University
cg.contributor.donorRoyal Society, United Kingdom
cg.creator.identifierHussein Abkallo: 0000-0002-5594-4418
cg.howPublishedFormally Published
cg.identifier.dataurlhttps://doi.org/10.5281/zenodo.14589291en
cg.identifier.dataurlhttps://doi.org/10.5281/zenodo.11176058en
cg.identifier.doihttps://doi.org/10.1371/journal.pone.0317958
cg.isijournalISI Journal
cg.issn1932-6203
cg.issue2
cg.journalPLOS One
cg.numbere0317958
cg.reviewStatusPeer Review
cg.speciesTrichomonas vaginalis
cg.subject.ilriDIAGNOSTICS
cg.subject.ilriHUMAN HEALTH
cg.subject.impactAreaNutrition, health and food security
cg.subject.sdgSDG 3 - Good health and well-being
cg.volume20
dc.contributor.authorShiluli, C.
dc.contributor.authorKamath, S.
dc.contributor.authorKanoi, B.N.
dc.contributor.authorKimani, R.
dc.contributor.authorOduor, Bernard
dc.contributor.authorAbkallo, Hussein M.
dc.contributor.authorMaina, M.
dc.contributor.authorWaweru, H.
dc.contributor.authorKamita, M.
dc.contributor.authorPamme, N.
dc.contributor.authorDupaty, J.
dc.contributor.authorKlapperich, C.M.
dc.contributor.authorLolabattu, S.R.
dc.contributor.authorGitaka, J.
dc.date.accessioned2025-02-12T05:59:35Zen
dc.date.available2025-02-12T05:59:35Zen
dc.identifier.urihttps://hdl.handle.net/10568/172975
dc.titleHighly sensitive molecular assay based on Identical Multi-Repeat Sequence (IMRS) algorithm for the detection of Trichomonas vaginalis infectionen
dcterms.abstractIntroduction: Annually, approximately 174 million people globally are affected by <i>Trichomonas vaginalis</i> (<i>T. vaginalis</i>) infection. Half of these infections occur in resource-limited regions. Untreated <i>T. vaginalis</i> infections are associated with complications such as pelvic inflammatory disease and adverse pregnancy outcomes mostly seen in women. In resource-limited regions, the World Health Organization (WHO) advocates for syndromic case management. However, this can lead to unnecessary treatment. Accurate diagnosis of <i>T. vaginalis</i> is required for effective and prompt treatment. Molecular tests such as Polymerase Chain Reaction (PCR) have the advantage of having a short turn-around time and allow the use of non-invasive specimens such as urine and vaginal swabs. However, these diagnostic techniques have numerous disadvantages such as high infrastructure costs, false negative and positive results, and interstrain variation among others. This study aimed to evaluate the use of identicen
dcterms.accessRightsOpen Access
dcterms.audienceAcademics
dcterms.audienceScientists
dcterms.available2025-02-07
dcterms.bibliographicCitationShiluli, C., Kamath, S., Kanoi, B.N., Kimani, R., Oduor, B., Abkallo, H.M., Maina, M., Waweru, H., Kamita, M., Pamme, N., Dupaty, J., Klapperich, C.M., Lolabattu, S.R. and Gitaka, J. 2025. Highly sensitive molecular assay based on Identical Multi-Repeat Sequence (IMRS) algorithm for the detection of <i>Trichomonas vaginalis</i> infection. PLOS ONE 20(2): e0317958.en
dcterms.issued2025-02-07
dcterms.languageen
dcterms.licenseCC0-1.0
dcterms.publisherPublic Library of Science
dcterms.subjectdiagnosisen
dcterms.subjecthealthen
dcterms.typeJournal Article

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