A practical guide to adjust micronutrient biomarkers for inflammation using the BRINDA method

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cg.authorship.typesNot CGIAR international institute
cg.contributor.affiliationEmory University
cg.contributor.affiliationLondon School of Hygiene and Tropical Medicine
cg.contributor.affiliationUniversity of Otago
cg.contributor.affiliationCenters for Disease Control and Prevention
cg.contributor.donorBill & Melinda Gates Foundation
cg.contributor.donorCenters for Disease Control and Prevention
cg.contributor.donorEunice Kennedy Shriver National Institute of Child Health and Human Development
cg.contributor.donorCGIAR Trust Fund
cg.contributor.donorUnited States Agency for International Development
cg.howPublishedFormally Published
cg.identifier.doihttps://doi.org/10.1016/j.tjnut.2023.02.016
cg.identifier.projectIFPRI - HarvestPlus
cg.identifier.publicationRankA Plus
cg.isijournalISI Journal
cg.issn0022-3166
cg.issue4
cg.journalJournal of Nutrition
cg.reviewStatusPeer Review
cg.volume153
dc.contributor.authorLuo, Hanqi
dc.contributor.authorGeng, Jiaxi
dc.contributor.authorZeiler, Madeleine
dc.contributor.authorNieckula, Emily
dc.contributor.authorSandalinas, Fanny
dc.contributor.authorWilliams, Anne
dc.contributor.authorYoung, Melissa F.
dc.contributor.authorSuchdev, Parminder S.
dc.date.accessioned2025-07-22T17:15:21Z
dc.date.available2025-07-22T17:15:21Z
dc.identifier.urihttps://hdl.handle.net/10568/175726
dc.titleA practical guide to adjust micronutrient biomarkers for inflammation using the BRINDA methoden
dcterms.abstractThe Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) research group was formed over a decade ago to improve the interpretation of micronutrient biomarkers in settings with inflammation. The BRINDA inflammation adjustment method uses regression correction to adjust for the confounding effects of inflammation on select micronutrient biomarkers and has provided important insights to micronutrient research, policy, and programming. However, users may face challenges when applying the BRINDA inflammation adjustment methods to their own data due to varying guidance on the adjustment approach for different biomarkers and the need to develop statistical programming to conduct these analyses. This may result in lost opportunities to have results of micronutrient data readily available during critical decision-making periods. Our research objectives are to 1) provide an all-in-one summary of the BRINDA method in adjusting multiple micronutrient biomarkers for inflammation, 2) evaluate whether malaria as a binary variable should be included in the BRINDA inflammation adjustment method, and 3) present standardized and user-friendly BRINDA adjustment R package and SAS macro. This paper serves as a practical guidebook for the BRINDA inflammation adjustment approach and aids users to use the BRINDA R package and SAS to streamline their analyses.en
dcterms.accessRightsOpen Access
dcterms.audienceAcademics
dcterms.bibliographicCitationLuo, Hanqi; Geng, Jiaxi; Zeiler, Madeleine; Nieckula, Emily; Sandalinas, Fanny; et al. 2023. A practical guide to adjust micronutrient biomarkers for inflammation using the BRINDA method. Journal of Nutrition 153(4): 1265-1272. https://doi.org/10.1016/j.tjnut.2023.02.016
dcterms.extent1265-1272
dcterms.issued2023-04
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherElsevier
dcterms.subjecttrace elements
dcterms.subjectbiomarkers
dcterms.subjectinflammation
dcterms.subjectcomputer applications
dcterms.typeJournal Article

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