Quantifying the transmission of antimicrobial resistance at the human and livestock interface with genomics

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cg.authorship.typesCGIAR and advanced research institute
cg.contributor.affiliationUniversity of Edinburgh
cg.contributor.affiliationInternational Livestock Research Institute
cg.contributor.crpAgriculture for Nutrition and Health
cg.contributor.donorJoint Programming Initiative on Antimicrobial Resistance
cg.contributor.donorDarwin Trust of Edinburgh
cg.contributor.donorBiotechnology and Biological Sciences Research Council, United Kingdom
cg.contributor.donorEconomic and Social Research Council, United Kingdom
cg.contributor.donorNatural Environment Research Council, United Kingdom
cg.contributor.donorNovo Nordisk Foundation
cg.creator.identifierDishon Muloi: 0000-0002-6236-2280
cg.howPublishedFormally Published
cg.identifier.doihttps://doi.org/10.1016/j.cmi.2020.09.019
cg.isijournalISI Journal
cg.issn1198-743X
cg.issue12
cg.journalClinical Microbiology and Infection
cg.reviewStatusPeer Review
cg.subject.ilriAGRI-HEALTH
cg.subject.ilriAMR
cg.subject.ilriGENETICS
cg.subject.ilriHUMAN HEALTH
cg.subject.ilriLIVESTOCK
cg.volume26
dc.contributor.authorWee, B.A.
dc.contributor.authorMuloi, D.M.
dc.contributor.authorBunnik, B.A.D. van
dc.date.accessioned2020-11-12T13:53:39Zen
dc.date.available2020-11-12T13:53:39Zen
dc.identifier.urihttps://hdl.handle.net/10568/110142
dc.titleQuantifying the transmission of antimicrobial resistance at the human and livestock interface with genomicsen
dcterms.abstractBackground Livestock have been implicated as a reservoir for antimicrobial resistance (AMR) that can spread to humans. Close proximity and ecological interfaces involving livestock have been posited as risk factors for the transmission of AMR. In spite of this, there are sparse data and limited agreement on the transmission dynamics that occur. Objectives To identify how genome sequencing approaches can be used to quantify the dynamics of AMR transmission at the human–livestock interface, and where current knowledge can be improved to better understand the impact of transmission on the spread of AMR. Sources Key articles investigating various aspects of AMR transmission at the human–livestock interface are discussed, with a focus on Escherichia coli. Content We recapitulate the current understanding of the transmission of AMR between humans and livestock based on current genomic and epidemiological approaches. We discuss how the use of well-designed, high-resolution genome sequencing studies can improve our understanding of the human–livestock interface. Implications A better understanding of the human–livestock interface will aid in the development of evidence-based and effective One Health interventions that can ultimately reduce the burden of AMR in humans.en
dcterms.accessRightsOpen Access
dcterms.audienceScientists
dcterms.bibliographicCitationWee, B.A., Muloi, D.M. and Bunnik, B.A.D. van. 2020. Quantifying the transmission of antimicrobial resistance at the human and livestock interface with genomics. Clinical Microbiology and Infection 26(12): 1612–1616.en
dcterms.extentp. 1612-1616
dcterms.issued2020-12
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherElsevier
dcterms.subjectantimicrobial resistanceen
dcterms.subjectlivestocken
dcterms.subjecthealthen
dcterms.subjecthumansen
dcterms.subjectgenomicsen
dcterms.typeJournal Article

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