Preliminary efficacy investigations of oral fipronil against Anopheles arabiensis when administered to Zebu cattle (Bos indicus) under field conditions

Simple item page
cg.authorship.typesCGIAR and developing country institute
cg.authorship.typesCGIAR and advanced research institute
cg.contributor.affiliationGenesis Laboratories, Inc.
cg.contributor.affiliationInternational Livestock Research Institute
cg.contributor.affiliationEXCELVET-Consultants
cg.contributor.donorBill & Melinda Gates Foundation
cg.coverage.countryKenya
cg.coverage.iso3166-alpha2KE
cg.coverage.regionAfrica
cg.coverage.regionEastern Africa
cg.creator.identifierNaftaly Githaka: 0000-0003-4530-7164
cg.creator.identifierVishvanath Nene: 0000-0001-7066-4169
cg.howPublishedFormally Published
cg.identifier.doihttps://doi.org/10.1016/j.actatropica.2017.07.030
cg.isijournalISI Journal
cg.issn0001-706X
cg.journalActa Tropica
cg.reviewStatusPeer Review
cg.subject.ilriANIMAL HEALTH
cg.subject.ilriCATTLE
cg.subject.ilriDISEASE CONTROL
cg.subject.ilriHEALTH
cg.volume176
dc.contributor.authorPoché, R.M.
dc.contributor.authorGithaka, Naftaly W.
dc.contributor.authorGool, F. van
dc.contributor.authorKading, R.C.
dc.contributor.authorHartman, D.
dc.contributor.authorPolyakova, L.
dc.contributor.authorAbworo, Edward O.
dc.contributor.authorNene, Vishvanath M.
dc.contributor.authorLozano Fuentes, S.
dc.date.accessioned2017-08-02T09:29:30Zen
dc.date.available2017-08-02T09:29:30Zen
dc.identifier.urihttps://hdl.handle.net/10568/82979
dc.titlePreliminary efficacy investigations of oral fipronil against Anopheles arabiensis when administered to Zebu cattle (Bos indicus) under field conditionsen
dcterms.abstractGlobally, malaria remains one of the most important vector-borne diseases despite the extensive use of vector control, including indoor residual spraying (IRS) and insecticide-treated nets (ITNs). These control methods target endophagic vectors, whereas some malaria vectors, such as Anopheles arabiensis, preferentially feed outdoors on cattle, making it a complicated vector to control using conventional strategies. Our study evaluated whether treating cattle with a capsule containing the active ingredient (AI) fipronil could reduce vector density and sporozoite rates, and alter blood feeding behavior, when applied in a small-scale field study. A pilot field study was carried out in the Samia District, Western Kenya, from May to July 2015. Four plots, each comprised of 50 huts used for sleeping, were randomly designated to serve as control or treatment. A week before cattle treatment, baseline mosquito collections were performed inside the houses using mechanical aspirators. Animals in the treatment (and buffer) were administered a single oral application of fipronil at ∼0.5 mg/kg of body weight. Indoor mosquito collections were performed once a week for four weeks following treatment. Female mosquitoes were first identified morphologically to species complex, followed by PCR-based methods to obtain species identity, sporozoite presence, and the host source of the blood meal. All three species of anophelines found in the study area (An. gambiae s.s., An. arabiensis, An. funestus s.s.) were actively transmitting Plasmodium falciparumduring the study period. The indoor resting density of An. arabiensis was significantly reduced in treatment plot one at three weeks post-treatment (T1) (efficacy = 89%; T1 density = 0.08, 95% credibility intervals [0.05, 0.10]; control plot density = 0.78 [0.22, 0.29]) and at four weeks post-treatment (efficacy = 64%; T1 density = 0.16 [0.08, 0.14]; control plot density = 0.48 [0.17, 0.22]). The reduction of An. arabiensis mosquitoes captured in the treatment plot two was higher: zero females were collected after treatment. The indoor resting density of An. gambiae s.s. was not significantly different between the treatment (T1, T2) and their corresponding control plots (C1, C2). An. funestus s.s. showed an increase in density over time. The results of this preliminary study suggest that treating cattle orally with fipronil, to target exophagic and zoophagic malaria vectors, could be a valuable control strategy to supplement existing vector control interventions which target endophilic anthropophilic species.en
dcterms.accessRightsOpen Access
dcterms.audienceScientists
dcterms.bibliographicCitationPoché, R.M., Githaka, N., Gool, F. van, Kading, R.C., Hartman, D., Polyakova, L., Abworo, E.O., Nene, V. and Lozano-Fuentes, S. 2017. Preliminary efficacy investigations of oral fipronil against Anopheles arabiensis when administered to Zebu cattle (Bos indicus) under field conditions. Acta Tropica 176: 126–133.en
dcterms.extent126-133
dcterms.issued2017-12
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherElsevier
dcterms.subjectanimal healthen
dcterms.subjectcattleen
dcterms.subjecthealthen
dcterms.typeJournal Article

Files

License bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.75 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ILRI articles in journals
ILRI animal and human health program outputs (2017–2024)
ILRI Tick unit